Antonio Filippi
Studies on flavonoids’s transport: physiological role in oxidative stress and implications in the regulation of cellular senescence.
Supervisor : Enrico Braidot
Flavonoids are among the most important secondary metabolites in plants and essential for human health as integral elements of the diet. Their antioxidant activity is documented by extensive literature and recently many models have been proposed in which they are also involved in cellular senescence as well as in biotic and abiotic oxidative stress response.
Although an intense experimental activity in plants has allowed a precise identification of the flavonoid biosynthetic pathway, the mechanisms of accumulation are still largely unknown. It is therefore crucial to understand what are the models of transport in different cellular compartments and the enzymes involved too. A more complete and comprehensive transport activities description, whether active or passive, could also promote the understanding about translocation of flavonoids in tissues and organs of the plant away from the sites of synthesis and during different phenological stages .
This information will be crucial to fully define the strategies that regulate and induce the accumulation of phenolic metabolites, taking grape, on which you can perform analysis purposes using cell cultures "in vitro" . This survey tool will allow you to effectively analyze at the cellular level the role of flavonoids in senescence, which is already recognized at the macroscopic level involvement .
Future goals obtainable from the knowledge gained will cover the design and development of agricultural techniques that can stimulate the transport and the accumulation of flavonoids in grape.
Biography and contacts
Antonio Filippi was born in 1986 in Monfalcone-Italy. In 2008 graduated in Agrarian Biotechnology (104/110) and 2010 graduated in Functional Genimics (108/110) at Trieste University (Italy). In 2014 he started the doctoral course at the PhD school “Agriculture Science and Biotechnology” at the University of Udine.
[Phone 0432558786]